Inhibition of rat liver and kidney arginase by cadmium ion
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چکیده
منابع مشابه
Curcumin inhibits adenosine deaminase and arginase activities in cadmium-induced renal toxicity in rat kidney.
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal active phytochemical in turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25...
متن کاملMolecular characteristics of rat liver arginase.
The molecular weight of approximately 1,500-fold purified arginase from rat liver (specific activity = 19,500 pmoles of urea per min at 25’ per mg of protein nitrogen) was determined by the method of sedimentation equilibrium to be 118,000. The sedimentation velocity constant is 6.1 S, the diffusion coefficient 5.2 X 10U7 cm2 per sec. Alteration in pH, removal of Mn2+, and replacement of Mn2+ b...
متن کاملOn molecular sizes of rat liver arginase.
Arginase exists as 2 or more molecular species in the size profile of the soluble macromolecules of rat liver in the absence of added Mn@. The principal species is that of approximately 120,000 molecular weight, as previously re ported by others. In addition, after activation by Mn@ , there are detectable small but significant amounts of arginase of about 30,000—40,000 molecular weight, presu...
متن کاملDistribution Pattern of Cadmium in Liver and Kidney of Broiler Chicken: An Experimental Study
Background: Cadmium (Cd) is not considered as essential element for living organisms, therefore its presence in tissues is considered as toxic element. From food hazards control point of view, information on the distribution of these toxic elements in the animal tissues is very important. The present study was designed to evaluate Cd distribution pattern in kidney and liver of broiler chicken. ...
متن کاملInhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone).
The effect of methylglyoxal bis(guanylhydrazone), a substance known to inhibit putrescine-dependent S-adenosyl-l-methionine decarboxylase, on polyamine metabolism in liver and kidney was investigated. Almost complete inhibition of the incorporation of putrescine into spermidine was obtained up to 8h after administration of 80mg of methylglyoxal bis(guanylhydrazone)/kg body wt. by intraperitonea...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2006
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756360500483420